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sirolimus
Product Detailed
Related Categories:Pharmaceutical
Sirolimus, white crystal powder,98%-102% purity. water not more than 0.5%.
Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It prevents activation of T cells and B-cells by inhibiting their response to interleukin-2(IL-2).
Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway.
Specifications:
| Appearance: | White crystal powder |
| Assay(Dried basis): | 98.0% min. |
| Tautomer: | 3.0% max. |
| Any impurity: | 1.0% max. |
| Total impurity: | 3.0% max |
| Loss on drying: | 1.0% max. |
| Residue in ignition: | 0.5% max. |
| Heavy metals: 20ppm max |
sirolimus